Group: Per Stenberg
Research Title: Epigenomics
Our aim is to understand how chromatin modifying proteins are recruited to their sites of action.
The control of gene expression is highly complex in all organisms, requiring major energetic inputs and the maintenance of intricate structures and mechanisms. Consequently, approximately 10% of proteins in the human genome appear to be involved in gene regulation. Many of these proteins bind directly to the DNA or chromatin and to understand gene regulation we need to understand how the regulatory proteins are targeted to their sites of action. Using computational methods we study sequence variation and chromatin structure across entire eukaryotic genomes. We also develop computational tools to handle the large amounts of data produced by the new generation tiling array and deep sequencing technologies.
* Targeting of chromatin factors
* Chromosome specific sequence composition and chromosomal evolution
* Linking chromatin structure and gene expression
* Bioinformatics on tiling-, micro-array and deep sequencing data
Software developed in the group
- Genomics data analysis
- Epigenomics data analysis