Group: Per Stenberg

Research Title: Epigenomics

Our aim is to understand how chromatin modifying proteins are recruited to their sites of action.

The control of gene expression is highly complex in all organisms, requiring major energetic inputs and the maintenance of intricate structures and mechanisms. Consequently, approximately 10% of proteins in the human genome appear to be involved in gene regulation. Many of these proteins bind directly to the DNA or chromatin and to understand gene regulation we need to understand how the regulatory proteins are targeted to their sites of action. Using computational methods we study sequence variation and chromatin structure across entire eukaryotic genomes. We also develop computational tools to handle the large amounts of data produced by the new generation tiling array and deep sequencing technologies.

Projects
  *  Targeting of chromatin factors
  *  Chromosome specific sequence composition and chromosomal evolution
  *  Linking chromatin structure and gene expression
  *  Bioinformatics on tiling-, micro-array and deep sequencing data

Software developed in the group

MLGsim
Sequence word aligner
Skewness handling

Techniques

  • Genomics data analysis
  • Epigenomics data analysis
  • Bioinformatics
  • Statistics

Publications

Author

Title

Year sorteringsordning

Fulltext

Kahn, Tatyana G.
Stenberg, Per
Pirrotta, Vincenzo; et al.

Combinatorial Interactions Are Required for the Efficient Recruitment of Pho Repressive Complex (PhoRC) to Polycomb Response Elements
PLOS Genetics, 10(7): e1004495-

2014

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Stenberg, Per
Saura, Anssi

Meiosis and Its Deviations in Polyploid Animals
Cytogenetic and Genome Research, 140(2-4): 185-203

2013

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Lundberg, Lina E
Stenberg, Per
Larsson, Jan

HP1a, Su(var)3-9, SETDB1 and POF stimulate or repress gene expression depending on genomic position, gene length and expression pattern in Drosophila melanogaster
Nucleic Acids Research

2013

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Philip, Philge
Stenberg, Per

Male X-linked genes in Drosophila melanogaster are compensated independently of the Male-Specific Lethal complex
Epigenetics & Chromatin, 6(Article number: 35)

2013

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Figueiredo, Margarida L A
Philip, Philge
Stenberg, Per; et al.

HP1a Recruitment to Promoters Is Independent of H3K9 Methylation in Drosophila melanogaster
PLoS genetics, 8(11): e1003061-

2012

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Holmqvist, Per-Henrik
Boija, Ann
Philip, Philge; et al.

Preferential Genome Targeting of the CBP Co-Activator by Rel and Smad Proteins in Early Drosophila melanogaster Embryos
PLoS Genetics, 8(6): e1002769-

2012

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Johansson, Anna-Mia
Stenberg, Per
Allgardsson, Anders; et al.

POF regulates the expression of genes on the fourth chromosome in Drosophila melanogaster by binding to nascent RNA
Molecular and Cellular Biology, 32(11): 2121-2134

2012

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Philip, Philge
Pettersson, Fredrik
Stenberg, Per

Sequence signatures involved in targeting the male-specific lethal complex to X-chromosomal genes in Drosophila melanogaster
BMC Genomics, 13: 97-

2012

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Lundberg, Lina E
Figueiredo, Margarida L A
Stenberg, Per; et al.

Buffering and proteolysis are induced by segmental monosomy in Drosophila melanogaster
Nucleic Acids Research, 40(13): 5926-5937

2012

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Johansson, Anna-Mia
Allgardsson, Anders
Stenberg, Per; et al.

msl2 mRNA is bound by free nuclear MSL complex in Drosophila melanogaster
Nucleic Acids Research, 39(15): 6428-6439

2011

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Page Editor: Per Stenberg
2014-03-18

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Contact Information

Department of Molecular Biology
Umeå University
901 87 Umeå 

Visiting Address
6K och 6L, Sjukhusområdet

Tel:  +46 (0)90-7856777

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